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SCDMDG presents:

Drug Metabolism and Chemical Structural Alerts

Dr. Sidney Nelson, PhD
Professor, Department of Medicinal Chemistry
Dean, School of Pharmacy
University of Washington

Seattle, WA

Several organic chemical substructures present in a variety of drugs have been found to be metabolized to reactive intermediates that can perturb cellular homeostasis. This presentation will review those substructures that have been associated with substantial risk of toxicity in humans. Structural analogs will be highlighted as useful tools both to identify specific substructures with toxic liability, and to characterize likely mechanisms of reactive metabolite formation. Some examples will be provided of how this paradigm can be used to identify genomic and proteomic changes in cells associated with some substructures that may eventually provide predictive biomarkers of cellular injury.

Dr. Nelson, Professor of Medicinal Chemistry and Dean of the School of Pharmacy, University of Washington, enjoys both teaching and research. He has received the John J. Abel Award from ASPET for research as a young investigator (1981), was elected a Fellow of AAAS (1986), received the Sato International Award for research from the Japanese Pharmaceutical Society (1992) and the School of Pharmacy Gibaldi Excellence in Teaching Award (1995), was a Wellcome Visiting Professor in Basic Medical Sciences (1998), and was listed as an ISI Highly Cited Author (2002). He has over 250 research publications, one patent and one licensed software package.


Date: Wednesday, September 27, 2006 – 5:00 p.m. (Buffet), 7:00 p.m. (Presentation)
Location: Salk Institute, Frederic de Hoffmann Auditorium


Prior presentations:

Speaker Topic Date
Richard B. Kim, MD Relevance and Utility of Transporters to Drug Discovery and Development September 21, 2005
Dr. Frederick P. Guengerich, Ph.D. Human Cytochrome P450 2A6 as a Case History:  Flavors, Smoke, Blue Roses, New Drugs & Basics of a P450 April 27, 2005
Dr. Leslie Benet, Ph.D. Predicting Drug Disposition via Application of BCS: Transport/Absorption/Elimination Interplay and BDDCS September 29, 2004
Dr. Christopher A. Lipinski, Ph.D. ADME/Tox: How Low Can You Go And How Do You Recover? April 21, 2004


SCDMDG gratefully acknowledges sponsorship by:

Quest Pharmaceutical In Vitro Technologies Hitachi
Cellz Direct Becton Dickinson Bruker
Eksigent Pfizer  

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