Drug Metabolism and Chemical Structural Alerts Dr. Sidney Nelson, PhD
Professor, Department of Medicinal Chemistry
Dean, School of
Pharmacy
University of Washington
Seattle, WA
Several organic chemical substructures present in a variety of drugs
have been found to be metabolized to reactive intermediates that can
perturb cellular homeostasis. This presentation will review those
substructures that have been associated with substantial risk of
toxicity in humans. Structural analogs will be highlighted as useful
tools both to identify specific substructures with toxic liability, and
to characterize likely mechanisms of reactive metabolite formation. Some
examples will be provided of how this paradigm can be used to identify
genomic and proteomic changes in cells associated with some
substructures that may eventually provide predictive biomarkers of
cellular injury.
Dr. Nelson, Professor of Medicinal Chemistry and Dean of the School of
Pharmacy, University of Washington, enjoys both teaching and research.
He has received the John J. Abel Award from ASPET for research as a
young investigator (1981), was elected a Fellow of AAAS (1986), received
the Sato International Award for research from the Japanese
Pharmaceutical Society (1992) and the School of Pharmacy Gibaldi
Excellence in Teaching Award (1995), was a Wellcome Visiting Professor
in Basic Medical Sciences (1998), and was listed as an ISI Highly Cited
Author (2002). He has over 250 research publications, one patent and
one licensed software package.